Endocrine Abstracts

Background: Recent advances in next-generation sequencing technology have greatly increased the number of Variants of Uncertain Significance (VUS) encountered in clinical practice. Herein, we present difficulty in diagnostic path and challenges in a premenopausal woman with an unusual fracture history and osteoporosis.Clinical Case: A 37-year-old Thai woman with no known underlying disease was diagnosed with osteoporosis (a BMD Z-score of -2.6 a...

Background: People with type 2diabetes (T2D) often referred as cardiovascular disease (CVD) risk equivalent. However, CVD risk in diabetes varies greatly and substantial proportion of people with T2D have low CVD risk as with the general healthy population. The latest European Society of Cardiology (ESC) guidelines 2023 endorsed the T2D-specific CVD risk score (SCORE2-Diabetes) for people with T2D. However, current prediction models are developed from non-Asian populations, an...